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Melatonin down regulates the inflammatory response after spinal cord injury Melatonin treatment can significantly reverse the expression of inflammatory related factors after SCI, such as IL-17 and IFN-, MCP-1 (Jing et al., 2019), NOD-like receptor protein 3 (NLRP3), IL-1 , and caspase-1 (Xu et al., 2019