constipation retatrutide Side Effects Guide: 21 Proven Remedies That Work Retatrutide Constipation: Causes, Timeline &

Diabetes Technol Ther 9:109121

Trial Metric Retatrutide 12mg (TRIUMPH-4) Semaglutide 2.4mg (STEP 1) Mean Weight Loss 28.7% at 68 weeks 14.9% at 68 weeks Mechanism Triple agonist (GLP-1/GIP/GCGR) Single agonist (GLP-1) FDA Status Phase 3 (investigational) Approved (Wegovy) Dosing Weekly subcutaneous Weekly subcutaneous Common Adverse Events GI (nausea, vomiting, diarrhea), dysesthesia GI (nausea, vomiting, diarrhea) Important caveat: These results come from different trial populations and study designs

This is normal and is included to allow the pen to be primed before each use

doi: 10.3390/metabo13050587

CMS launched the BALANCE model in December 2025, which will expand GLP-1 coverage through Medicare Part D starting January 2027, with beneficiaries paying $50/month

The clinical data shows that efficacy and GI tolerance are not perfectly correlated