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Yes I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as ClinicalTrials.gov

Imitation drugs, unexpected benefits, serious pitfallsheres what comes next as GLP-1 medications continue to rise in popularity

Tirzepatide, a dual GLP-1 and GIP receptor agonist, has...

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Clinically Enhanced Benefits & Key Bioactive Pathways

However, that is not the reality: even diabetic patients treated with GLP-1 RAs are more likely to stop them than other second-line anti-diabetic medicines.3 That study didnt report why 50% of diabetics on GLP-1 RAs discontinued them, but gastrointestinal (GI) adverse events were a suggested cause.3 Adverse events are just one of a number of reasons that people stop using these drugs, as follows.