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26,27 A Phase II trial in T2D showed a 1% reduction in HbA1c (Diabetes Control and Complications Trial units) and approximately 1.7% body weight reduction over 12 weeks, in comparison to placebo, but a further comparison to an open-label liraglutide active treatment control group was less impressive

Cohort entry was the date of a newly filled prescription of SGLT-2 inhibitors, GLP-1 receptor agonists, or DPP-4 inhibitors

doi:10.2337/diabetes.42.11.1678

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They contain sorbitol, a natural sugar alcohol that draws water into the bowel, and fiber, both of which can help with bowel regularity while on GLP-1 drugs

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts