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While proper hydration is important, excessive water intake (more than 3-4 litres daily) without electrolyte replacement could potentially cause electrolyte imbalances

Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins

6 Pharmacological responses exhibited by endogenous ligands GLP-1 and oxyntomodulin in the presence of TT-OAD2

While no serious injuries were sustained, taking part in duels was forbidden

BMJ 342 , d1309 (2011)

However, the systemic effects on salivary glands are likely similar regardless of administration route