can you take metformin with glp 1 for Weight Loss: How It Works and What to Expect Frontiers | Understanding the action

Courilleau, D

We wrote an entire article on strength training vs cardio for GLP-1 users because this misconception is so widespread

We also pretreated cells with another AMPK activator, metformin, in MG-treated INS-1 and MIN6 cells, and found that pretreatment with metformin neither aggravated nor rescued the MG-induced cell death (Fig.6E)

[DOI] [PubMed] 30.Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al

This could theoretically lead to more degradation of the drug in the stomach and slightly reduced bioavailability

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