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2.2 Indications The currently approved indications for these agents include: Type 2 diabetes mellitus Overweight and obesity Beyond diabetes and obesity, further indications under investigation for GLP1 RAs include: Osteoarthritis Obstructive sleep apnea Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis 2.3 Benefits and Harms of Continuation/Discontinuation in the Perioperative Period: 2.3.1 Benefits: According to the guidelines, the acute use of these drugs may offer benefits based on published data: Improved perioperative glycemic control Lower postoperative insulin requirements Reduced risk of hypoglycemia These benefits may lead to reduced complications associated with hyperglycemia (such as a shorter hospital stay, fewer surgical site infections, less acute kidney injury, fewer acute coronary syndromes, reduced critical care admissions, and shorter durations on a ventilator) Improved cardiovascular outcomes 2.3.2 Harms There is an increased risk of pulmonary aspiration

Accessed March 25, 2026

Benefits GLP-1 agonists are effective in weight loss as they delay gastric emptying, induce satiety, and decrease food These agents have been successfully studied in obese, non-diabetic patients Weight loss results seen as early as two weeks into treatment Liraglutide especially is shown to be effective for long-term (2 year) weight loss Liraglutide even produces greater weight loss results than orlistat More favorable effects on HbA1c and blood pressure seen with liraglutide vs

Coincidentally, the patient had started on semaglutide just before the start of her history of chronic UTIs