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Bracesco, N., Snchez, A

Exenatide (Byetta), approved in 2005, was based on exendin-4, a naturally occurring peptide from the Gila monster with inherent DPP-4 resistance

The research was published Monday in The Lancet Diabetes & Endocrinology

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Scientific References Tolerability, safety and pharmacodynamics of oral, small-molecule glucagon-like peptide-1 receptor agonist danuglipron for type 2 diabetes: A 12-week, randomized, placebo-controlled, Phase 2 study comparing different dose-escalation schemes

Role of Exendin-4 in the Gila Monster: Further Lessons Regarding Human Oral Glucagon-Like Peptide-1 Therapy