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both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

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These findings suggest potential neuroprotective benefits of semaglutide, especially regarding cognitive health, and call for further research to validate its use in treating cognitive deficits and substance misuse in patients with T2DM (87)

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