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From baseline to week 68, the mean change in knee pain, assessed using the WOMAC pain score, was a reduction of 41.7 points for semaglutide and a decrease of 27.5 points for placebo, with an estimated treatment difference of 14.1 points, which was statistically significant [167]

Anti-Inflammatory Effects: GLP-1 medications may reduce inflammation, address insulin resistance, and improve metabolic function by reducing visceral fat

Global Oral Non Peptide GLP 1 Receptor Agonist Market Size is valued at USD 102.77 Bn in 2025 and is predicted to reach USD 243.16 Bn by the year 2035 at a 9.2% CAGR during the forecast period for 2026 to 2035

Differences in patient populations, baseline risk factors, and treatment exposure further complicate the interpretation of findings (Gough et al., 2014

Diabetes Obes Metab 2017;19:123341.PubMed 83

One notable approach involves the use of dibenzazepine (DBZ), a -secretase/Notch pathway inhibitor