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Its efficacy and safety in improving blood sugar control have led to its approval by the United States Food and Drug Administration (USFDA) in May 2022 for treating T2D

All GLP-1 receptor agonists with a different route of administration faithfully serve its role as an incretin hormone, stimulating insulin secretion on nutrient ingestion

Because it works this way on different metabolic pathways, retatrutide is becoming a strong option in new weight loss medicines

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Almost everyone is overweight: 71% of Americans are either overweight or obese

80 While the clinical significance of this heart rate increase remains uncertain, it raises theoretical concerns in patients with ischemic heart disease or arrhythmias and may counteract some of the antihypertensive benefit of GLP-1 RAs