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Significant results are often only observed after (mostly unplanned) post-hoc stratification [199, 200], while pre-registered stratified analyses did not show effects [201]

Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, Gomes AP, Ward TM, Minor RK, Blouin MJ, Schwab M, Pollak M, Zhang Y, Yu Y, Becker KG, Bohr VA, Ingram DK, Sinclair DA, Wolf NS, Spindler SR, Bernier M, de Cabo R

Figure 1 4 Overview of the GLP-1 mechanism GLP-1 is an incretin hormone composed of 3031 amino acids, produced by post-translational processing of proglucagon and secreted by intestinal L-cells in response to nutritional and inflammatory stimuli, as well as by neurons in the brainstem

Tirzepatide has also shown some promising results with up to 8% absolute reduction in liver fat content in a RCT

GLP-1 receptor agonists are a class of medications that mimic the action of glucagon-like peptide-1, a naturally occurring hormone produced in the intestine

In an intervention study on meal sequence, individuals with prediabetes were instructed to consume GLP-1-stimulating foods, such as meat, fish, or salad, at the beginning of a meal, followed by a 5-min waiting period before consuming carbohydrate-rich foods, such as rice or bread