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When added to tirzepatide, the additional weight loss is modest but the metabolic benefits (improved insulin sensitivity, enhanced GLP-1 signaling, reduced hepatic fat) contribute to better overall outcomes and potentially more sustainable long-term weight maintenance
doi: 10.1073/pnas.1100495108

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Mean total body fat loss: Postmenopausal women using hormone therapy: 19.9 percent Premenopausal women: 18.7 percent Perimenopausal women: 18.6 percent Postmenopausal women not using hormone therapy: 15.6 percent The difference is striking

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