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ACHIEVE-5 (NCT06109311) A placebo-controlled trial in type 2 diabetes, complementing the active comparator studies by providing clean placebo-adjusted efficacy estimates

Its mechanisms of action include: Stimulating insulin secretion from pancreatic -cells in a glucose-dependent manner Suppressing glucagon release , reducing hepatic glucose production Slowing gastric emptying , which reduces postprandial glucose spikes Promoting satiety , leading to reduced caloric intake and potential weight loss Semaglutide has a half-life of approximately 1 week , allowing for once-weekly dosing , which improves adherence compared to daily injections

Your diabetes care team can provide personalised advice on blood glucose targets, medication adjustments, and self-management strategies

Sex and estrogens alter the action of glucagon-like peptide-1 on reward

Protein shakes designed for GLP-1 users help maintain muscle mass during rapid weight loss