compounded semaglutide still available (GLP-1) Drugmakers battle pharmacies over compounded

With increasing challenges over time

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Glucagon-like peptide-1 (GLP-1) is a gut-derived incretin hormone secreted by enteroendocrine L-cells in response to nutrient ingestion, with additional production by preproglucagon neurons in the Nucleus Tractus Solitarius (NTS)

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On first sight, this could indicate that there is no principal barrier for endogenous GLP1 to reach at least this part of the brain, though it would require a large enough dose to overcome the physiological inactivation of the native, gutderived GLP1 in the circulation