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In recent years, GLP-1RA and DPP4-i therapies are known to have pleiotropic effects, such as a reduction in oxidative stress, autophagy regulation, metabolic reprogramming, enhancement of anti-inflammatory signaling, regulation of gene expression, and being neuroprotective

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Publicado : Escrito por Jordan Caulfield y revisado mdicamente por la Dra

The scientific literature continues to expand with new findings

argue that higher concentrations of metformin are necessary in in vitro cell culture protocols because the abundance of growth factors and nutrients, such as glucose, reduces the sensitivity to the inhibitory effects of metformin thus reflecting the importance of glucose and the Warburg effect for cancer cell growth as well as the importance of glycemic control in diabetes (249)

Again, some level of consideration will have to be made for initial starting BMI, but just like the obese patients, a treat-to-target dose that considers weight + A1c goals should be the aim going forward