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Heppner et al., 2015), and immunocytochemistry ( In vitro patch-clamp electrophysiological recordings revealed that modulating the electrophysiological properties of both POMC and cocaine- and amphetamine-regulated transcript (CART) neurons (POMC/CART neurons) and NPY/AgRP neurons are the possible mechanism of liraglutide-induced weight loss (Secher et al., 2014)

While the weight loss is moderate compared to newer agents, the tolerability profile is genuinely superior for many individuals

Implications and Future Research The INFORM survey underscores the dual potential of semaglutide in weight management addressing both physiological and psychological aspects of obesity