glp 1 gip gcg LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept: Cell Metabolism Frontiers | Striking the Balance:

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39 , 40 This was evidenced in female rats wherein acute central GLP1 administration during the proestrous phase influenced the anterior pituitary to increase the synthesis of ovulationpromoting LH, leading to an increase in the number of mature follicles, and elevated implantation and live birth rate

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c Performed significantly more poorly than comparator

Principally, GLP-1 induces glucose-dependent insulin secretion from pancreatic -cells, 10,11 decreases plasma glucagon concentrations, 11 and delays gastric emptying

Shteyer, E., Liao, Y., Muglia, L