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Finally, a very recent proteomic study comparing agonist-induced phosphorylation patterns among GLP-1R, GCGR, and GIPR, demonstrated that GLP-1R undergoes minimal, barely detectable (~15%) agonist-induced phosphorylation leading to arrestin recruitment, but not to desensitization or internalization [41], thereby further reinforcing the notion of the resistance of GLP-1R to homologous desensitization and the actions of arrestins

[5] [6] Similarly, men who lose weight often experience improvements in testosterone levels and sperm parameters

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