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Mechanism of fat-induced hepatic gluconeogenesis: effect of metformin

This early effect helps you eat fewer calories and lose weight

But the medication is only half the equation

GLP-1 for type 2 diabetes

Avoiding high-fat foods, artificial sweeteners, and caffeine during dose escalation weeks reduces irritation and cramping

Limit: weight regain is faster upon drug discontinuation than after surgery, and cumulative chronic treatment cost may equal or exceed surgery at 5-7 years
