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A paper published this week in JAMA Psychiatry found semaglutide, the active ingredient in GLP-1 drugs like Ozempic and Wegovy, "significantly improved" motivation in patients with major depressive disorder, or MDD a promising finding because lack of motivation and related disruptions to the brains reward pathways play a critical role in many other psychiatric conditions as well

Rosenstock J, Perkovic V, Johansen OE, Cooper ME, Kahn SE, Marx N, et al

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The difference is that the gatekeeper is the clinicians judgment and clinical process, not the insurers utilization rules

Alicic, J.J

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