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The following year, antagonism of the GIP receptor by palmitoylation of GIP analogues with N- and C-terminal modifications reduced body weight and improved metabolic control in high-fat-fed mice

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Hiura Y., Takiguchi S., Yamamoto K., Takahashi T., Kurokawa Y., Yamasaki M., Nakajima K., Miyata H., Fujiwara Y., Mori M., et al

It is believed that reduced concentrations of GLP-1 would result in loss of the pro-kinetic actions of GLP-1 in the colon [Citation26], causing constipation and abdominal discomfort, was further supported by the correlation between this and the intensity of abdominal pain (12)

As more people experience reduced appetite through medically supported weight management, supermarkets are responding with smaller ready meals, single-serve snacks and flexible packaging