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Losing over 100 pounds, improved blood pressure, improved cholesterol, less joint pain, more energy, normal A1C and blood glucose, says Emile Kettle, PA

Both medications mimic the same hormones, and taking both together can lead to complications

Among small-molecule oral GLP-1 candidates, orforglipron is the most clinically advanced and the only one to have completed multiple Phase 3 trials with positive results

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