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Description
New risks emerge for certain patients As GLP-1 drugs become more widely used across therapy areas, new risks are emerging, too

Weeks 5 through 8: the first therapeutic dose This is where things start to change
GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)

Ngan HY, Chong YY, Chien WT

Chronic treatment with the DualAG led to greater improvements in metabolic markers like insulin, leptin, and adiponectin compared to GLP-1R

Although calories and augmented alcohol metabolism are other aspects that might influence the data, these seem unlikely because the GLP-1 pathway suppresses drug responses that are independent of calories and because liraglutide does not change the blood alcohol levels (Vallof et al., 2015)
