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New risks emerge for certain patients As GLP-1 drugs become more widely used across therapy areas, new risks are emerging, too

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Weeks 5 through 8: the first therapeutic dose This is where things start to change

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GLP-1 receptor agonists have been shown in multiple studies to exert anti-inflammatory effects, including inhibition of monocyte chemotaxis, suppression of macrophage inflammatory responses, and AMPK-mediated downregulation of the NF-B signaling pathway, thereby reducing systemic inflammation (36)

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Ngan HY, Chong YY, Chien WT

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Chronic treatment with the DualAG led to greater improvements in metabolic markers like insulin, leptin, and adiponectin compared to GLP-1R

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Although calories and augmented alcohol metabolism are other aspects that might influence the data, these seem unlikely because the GLP-1 pathway suppresses drug responses that are independent of calories and because liraglutide does not change the blood alcohol levels (Vallof et al., 2015)

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