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However, the full therapeutic effects, including significant reductions in HbA1c levels and weight loss, typically become more pronounced within 4 to 12 weeks of consistent use

This reward modulation appears particularly relevant for binge-type eating disorders, where altered mesolimbic neurotransmission is documented and GLP-1 RAs suppress motivation for palatable foods [55]

In a seminal study, Gisondi et al

Each addresses a distinct physiological pathway, and together they create conditions that neither can achieve alone

Adjusting Your Dose: When to Pause or Reduce Dose escalation should be paused or reduced for persistent nausea, severe diarrhoea, acute illness, pancreatitis symptoms, or before surgery

Pregnancy and breastfeeding also contraindicate GLP-1 use
