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Nausea, vomiting, and diarrhea are more common during dose increases and generally improve over time
The Multiple-Hit Pathogenesis of Non-Alcoholic Fatty Liver Disease (NAFLD) Metabolism
Key findings relevant to injection site safety: Injection site reactions were not significantly higher in retatrutide groups compared to placebo The most common injection site reactions were transient redness and mild discomfort No participants discontinued due to injection site reactions The overall safety profile was consistent with other GLP-1 receptor agonists The more recent TRIUMPH-4 phase 3 trial confirmed these safety findings in a larger population
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