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Discovery of a novel oral proteasome inhibitor to Block NLRP3 inflammasome activation with anti-inflammation activity

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Notably, S303 has been implicated in feedback regulation of IRS2 signaling( 48 ), suggesting that RF-409 modifies proximal feedback timing

Fritschi, C., & Quinn, L

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Although generally safe and effective for modest weight loss, off-label use for weight loss has created access challenges for T2DM patients [3, 1315]
