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Simultaneously, its GLP-1 receptor agonist activity promotes glucose-dependent insulin release, suppresses inappropriate glucagon secretion, slows gastric emptying, and reduces appetite through central nervous system pathways

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Dose-response relationship in clinical trials The SURMOUNT clinical trial program tested tirzepatide at 5 mg, 10 mg, and 15 mg weekly doses

The production and expression of GIP is also noted in the central nervous system [18]

Bleeding-related events as adjacent gynaecological signals Although bleeding is not a vaginal mucosal endpoint, it is clinically adjacent because patients may describe spotting as vaginal bleeding and present alongside discharge/pain