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A recent study suggests that patients taking semaglutide may increase the risk of developing a rare condition called NAION (non-arteritic anterior ischemic optic neuropathy)

10.3390/microorganisms10030578 63 HrovatinK.Bastidas-PonceA.BakhtiM.ZappiaL.BttnerM.SalinnoC.et al (2023)

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Although no statistically significant differences were detected in AKT mRNA expression among groups, the downward trend observed in the STZ group may reflect impairment within the IRS-1/PI3K/AKT signalling axis, which has been associated with GSK-3 activation under diabetic conditions [38]