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J Physiol 592(21):46774696

& Kronenberg, S

Without appropriate management, recurrent exposure to stomach acid can damage the lining of the esophagus, leading to complications like esophagitis (inflammation), esophageal stricture (narrowing), or Barretts esophagus, a condition where the tissue lining the esophagus changes and can lead to cancer

Acute kidney injury, often in the context of GI fluid losses, underscores the importance of hydration counseling and renal function monitoring in susceptible patients, particularly during dose escalation

That leads to constipation, and more straining when opening your bowels, which in turn causes piles, small tears and anal skin tags. Constipation and straining are among the most common triggers for haemorrhoids, particularly when prolonged over weeks or months

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