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Chronic hyperglycemia in diabetes downregulates GIP receptor (GIPR) expression and impairs GIP-mediated insulin secretion [21], rendering high-doses of GIP infusions ineffective [22]

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( 10.1016/j.molmet.2021.101351) [DOI] [PMC free article] [PubMed] [Google Scholar] Drucker DJ & Holst JJ

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