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3), generating the resultant metabolite, GLP-1(9-36)-NH 2

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(2017) The gluco- and liporegulatory and vasodilatory effects of glucose-dependent insulinotropic polypeptide (GIP) are abolished by an antagonist of the human GIP receptor

GCG, Glucagon

38 Despite the speculation, hydrophobic amino acids like Leu or Met successfully replaced Glu 9 while retaining the same potency of GLP-1, suggesting that the negatively charged side chain of Glu 9 may not form an ion pair with a basic residue in the receptor or the peptide

Vomiting Diarrhea Constipation Indigestion Decreased appetiteLess Common but Serious Side Effects: Hypoglycemia (low blood sugar): Especially when used in combination with other diabetes medications like insulin