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Published Phase 2 effect sizes most prominently the ~24 percent mean body weight reduction at the 12 mg dose tier in the obesity Phase 2 (PMID 37366315) exceed those reported for dual or single agonists at comparable durations, an outcome that researchers attribute to the additional glucagon-arm contribution to body-composition and energy-expenditure pathways

For post-GLP-1 body contouring patients, this means procedures are designed to restore a natural body shape rather than create an artificial or overdone appearance

While these reactions are statistically rare, staying informed allows you to act quickly if you are among the small percentage of people who experience them

The researchers, led by Ravi Retnakaran, from Mount Sinai Hospital, Toronto, Canada, noted that the high cost of both GLP-1 agonists and insulin analogues is likely to be the major barrier to widespread adoption of the treatment