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The long-standing use of this drug in diabetes management has led to a lot of clinical data and trust from healthcare professionals, who often prescribe it as a go-to therapy

Summary: GLP-1 receptor agonists are not licensed or recommended for treating cortisol disorders and have no established direct therapeutic effect on cortisol levels in humans

This directly addresses the crepiness and laxity associated with rapid weight loss

[cited 2025 Nov 20]

It was approved by the Food and Drug Administration (FDA) in 2017 under three major brand names, Ozempic, Wegovy, and Rybelsus, primarily as a glucose-lowering agent for type 2 diabetes, to reduce cardiovascular risk and provide cardiovascular protection [3]