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This extended presence allows convenient once-weekly dosing but also means effectsboth therapeutic and adversepersist for several weeks after discontinuation

FDA labeling indicates no clinically relevant pharmacokinetic changes across the spectrum of hepatic impairment (Child-Pugh classes A-C), and no dose adjustment is recommended based on hepatic function

Zhao L et al

Address correspondence to: Hariom Yadav, 575 Patterson Avenue, Suite 2E-034, Biotech Place, Downtown, Department of Internal Medicine-Molecular Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA

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GLP-1 medications, including semaglutide (Wegovy and Ozempic) and tirzepatide (Zepbound and Mounjaro), work by mimicking a natural gut hormone that regulates hunger, blood sugar, and digestion