is tirzepatide better than metformin SURPASS-2: A Study of Tirzepatide Versus Semaglutide Once Weekly as Do You Still Need Metformin
Description
Many adverse drug reactions remain underreported because patients may ignore symptoms, healthcare professionals may not suspect drug involvement, or reporting systems may not be used actively

The trial randomized and dosed 94 people for the first 12 weeks of study

doi: 10.1111/eci.14292 9 PageMJMcKenzieJEBossuytPMBoutronIHoffmannTCMulrowCDet al
2020 Dec

They did get exposed to semaglutide

Food & Drug Administration advises against the use of quinine to treat nighttime leg cramps due to the drugs serious side effects
