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Selection reporting bias was found in 56 studies (74%)
We were able to show that the circulating form of DPP4 (sDPP4), which lacks the cytoplasmic domain and the transmembrane region, is cleaved off the membrane of human adipocytes and smooth muscle cells in a process called shedding by the involvement of matrix metalloproteases (MMPs) (3)
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Via interaction with CD45, the complex of ADA and DPP-4 enhances T-cell activation [22, 26]
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