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17,18 In the authors experience, it is often possible to eliminate the sulfonylurea altogether, which can be advantageous in terms of avoiding hypoglycemia, minimizing the complexity of the diabetes regimen, and augmenting the weight loss benefits of the GLP-1 RA

That is a net treatment effect of approximately 5.4%

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A woman who loses weight while preserving muscle, movement quality, confidence, and physical resilience is in a completely different long-term position than someone who simply becomes lighter on the scale

Combining them raises the risk of side effects without adding benefit

Hepatic steatosis, a further component of the metabolic syndrome, is known to be more common in patients with IBD 110 and GLP-1RAs have previously been shown to be effective for reducing liver fat content, 111 and this represents another potential benefit to GLP-1RA therapy