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Available evidence suggests that it functions by limiting oxidative stress, which is one of the leading causes of cellular injury and general aging

Rats receiving the chemotherapy agent cisplatin present dampened ghrelin presence in the hypothalamus [137] and increased gene expression for GHSR in this same region [138], suggesting that these effects could be attenuated by exogenous ghrelin

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These include: Nausea Vomiting Diarrhea Constipation Stomach pain Loss of appetite Serious side effects Less common but more serious side effects of semaglutide may include: Pancreatitis (inflammation of the pancreas) Kidney problems Gallbladder problems Hypoglycemia (low blood sugar) Diabetic retinopathy Hypersensitivity reactions (such as rash, hives, or difficulty breathing) Most of semaglutides side effects are short-lived, going away once your body gets used to the medication dosage