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Variables and outcomes Baseline demographic characteristics (age, age group, sex, race/ethnicity, payer type, geographic region) as of the index date (month and year) were captured

Current Evidence and Clinical Trial Findings Phase 2 data published in the NEJM (2023) showed dose-dependent body weight reductions with retatrutide over 48 weeks, with gastrointestinal side effects being the most commonly reported

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However, a similar A 2023 review of research that looked at multiple studies suggests that non-nutritive sweeteners have no immediate effects on the metabolic or endocrine systems

Research on long-term use (3+ years) shows sustained weight loss in those who remain on therapy

Insulin concentration was measured using a radioimmunoassay kit (North Biological Technology Research Institute, Beijing, China)