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Orforglipron from Eli Lilly represents the next generation of oral GLP-1 therapy

However, coverage for weight-loss-specific brands like Wegovy, Zepbound or Saxenda is not guaranteed and is often not included

Ambery P, Parker VE, Sumvoll M et al (2018) MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomized, controlled, double-blind, ascending dose and phase 2A study

It also triggers hormone release to delay the emptying of the stomach, sometimes causing nausea

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