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Those taking semaglutide had a 14.9% decrease in body weight compared to 2.4% the placebo group

It is assumed there would be a high percent of GI side effects as it affects gastric emptying
Semaglutide is a breakthrough medication originally developed for managing blood sugar in people with type 2 diabetes

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A pilot study of liraglutide, a GLP-1 receptor agonist, in patients with obesity and chronic migraine found that mean monthly headache days dropped from 19.8 to 10.7, a highly significant reduction
Similarly, chronic vomiting, constipation or heavy lifting can be associated with Hiatal hernias