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Thiazolidinediones (TZDs), which are peroxisome proliferator-activated receptor (PPAR)-gamma agonists, can cause dose-related fluid retention, when used in combination with insulin

Accordingly, it has several metabolic effects consistent with the actions of GLP-1 and glucagon (stimulation of insulin secretion, reduced appetite, increased energy expenditure), although whether these are important physiologically is uncertain (55)

Initially, GLP-1 medication was only for treating diabetes because one of the main roles of GLP-1 is to boost the bodys insulin production

Key symptoms Persistent feeling of queasiness or the urge to vomit Increased salivation (watering mouth) Retching or dry heaving Actual vomiting of stomach contents Loss of appetite Potential dehydration if vomiting is severe How common are nausea and vomiting with GLP-1 treatments

Tirzepatide outperforms dulaglutide for type 2 diabetes control

Thanks to ingredients like 5-HTP and saffron extract, some reviewers report feeling more satisfied after meals and less likely to snack out of boredom or stress