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We also found that CB0313.1 modulated gut microbiota composition, characterized by a decreased ratio of Firmicutes to Bacteroidetes, reduced Allobaculum bacteria that were abundant in HF diabetic mice and increased butyrate-producing bacteria

Mechanistic hypotheses include reduced leptin-driven T-helper (Th)1/Th17 activity, improved adipokine balance, and modulation of gut-thyroid axis pathways

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However, GLP-1 also has a positive effect on gut flora, nurturing a healthy microbiome that aids digestion and supports overall health

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Overeating on Wegovy can trigger nausea, vomiting, and digestive discomfort because the medication slows stomach emptying and reduces appetite signals