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And these side effects are a major reason for medication discontinuation

Most protocols involve a treatment phase followed by either dose reduction or discontinuation

Mechanistically, spexin signals primarily through galanin receptor subtypes GALR2 and GALR3, receptors with complex roles in nociception, mood regulation, and metabolic control

Interestingly, monomeric GLP-1R agonists, like semaglutide and liraglutide, as well as dual GLP-1R agonists like tirzepatide, have been FDA-approved for the treatment of T2DM and metabolic disorders, including chronic weight management in adults with obesity [32,33]

Some patients prefer injecting on an empty stomach because they feel less nauseous, while others notice no difference

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