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80,82 When MPTP was administered to rats or mice, substantial losses of DAergic neurons occurred, which were associated with a heightened inflammatory response

(2.3) Dosage Forms and Strengths JANUMET Tablets: sitagliptin 50 mg and metformin HCl 500 mg tablets sitagliptin 50 mg and metformin HCl 1000 mg tablets (3) Contraindications Warnings and Precautions Lactic Acidosis: See boxed warning

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To mitigate gastrointestinal side effects, the FDA recommends a gradual weekly increase in dosage

doi: 10.1085/jgp.200810044

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