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Third, the purpose of the prescription is not known consistently in claims data and therefore was not used as part of the selection criteria

185,186,187,188 In the future, GLP-1R agonists may benefit all patients with metabolic cardiovascular risk by slowing the progression of cardiac remodeling, thereby reducing cardiovascular risk

doi: 10.1523/ENEURO.0443-18.2019

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However, this increase appears to be due to the rapid and robust glucose-lowering in people with marked hyperglycemia and preexisting retinopathy phenomenon previously observed in studies of insulin