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Description
Participants receiving the highest dose of 12 mg lost an average of 24.2% of their body weight, compared to just 2.1% with placebo

In this patient, creatinine rapidly normalized after intravenous fluids, underscoring the importance of prompt volume repletion [11]

Qualmann C, Nauck MA, Holst JJ, rskov C, Creutzfeldt W

Factors that likely influence individual response include baseline heart rate, cardiovascular fitness level, autonomic nervous system tone, body composition, and potentially genetic variations in glucagon receptor density or sensitivity

However, address all other potential causes before switching, as the same factors that cause weight gain on tirzepatide may also affect semaglutide results

Although new drugs such as GLP-1 agonists show potential in controlling weight, appetite, and blood glucose in subjects with PWS, diet, physical activity, and behavioral modifications remain the main strategies to promote good metabolic health in these patients
