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In the STEP (Semaglutide Treatment Effect in People with Obesity) trials, Semaglutide injection demonstrated significant weight loss compared to placebo in individuals with obesity

[3] , [4] Achievement of target glucose levels, especially in the early years after T2D diagnosis, reduces the incidence and progression of microvascular complications and, in the long term (more than 10 years), is associated with reduced CV outcomes

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Contact your GP, trial coordinator, or a healthcare professional promptly but without the urgency of 999 if you experience: A widespread or rapidly spreading rash, particularly if accompanied by fever, joint pain, or malaise Blistering, peeling, or open sores on the skin, which may indicate a more serious dermatological reaction Persistent or worsening injection site reactions that do not resolve within a few days Skin changes accompanied by systemic symptoms such as fatigue, fever, or lymph node swelling Severe cutaneous adverse reactions (SCARs), such as Stevens-Johnson syndrome or toxic epidermal necrolysis, are rare but serious drug-related skin conditions requiring emergency assessment

Where Retatrutide Stands in Clinical Trials Retatrutide is currently in phase 3 evaluation through Eli Lilly's TRIUMPH trial programme, following phase 2 results showing up to 24.2% body weight loss over 48 weeks
