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It is important to distinguish between theoretical concerns, findings from animal studies, and actual evidence in human populations

Increased heart rate

15 , 16 Interestingly, the improvements in quality of life occurred independent of the degree of weight loss, possibly suggesting these improvements are from mechanisms beyond weight reduction alone

Palmer SC, Tendal B, Mustafa RA et al (2021) Sodiumglucose cotransporter protein-2 (SGLT-2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists for type 2 diabetes: systematic review and network meta-analysis of randomised controlled trials

[5] This is why GLP-1 receptor agonist drugs cause dramatic reductions in appetite they flood the brain with a much stronger, longer-lasting version of this natural "stop eating" signal

Human studies will need to establish durability, tolerability (esp